Lipids 1999;34(9):997-1000. Onakpoya IJ, Posadzki PP, Watson LK, Davies LA, Ernst E. The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials. Sebedio JL, Gnaedig S, Chardigny JM. Nutr Cancer 1999;33:53-7. Effect of conjugated linoleic acid on body fat accretion in overweight or obese children. Lipids 1998;33(8):803-809. J Oleo Sci 2017;66(7):723-33. A., Sehat, N., Mossoba, M. M., Kramer, J. K., Fritsche, J., Steinhart, H., and Ku, Y. Lipids 2000;35(7):777-782. J.Sports Med.Phys.Fitness 2006;46(4):570-577. A., de la Perriere, A. Madry E, Chudzicka-Strugala I, Grabanska-Martynska K, et al. Ebrahimi-Mameghani M, Jamali H, Mahdavi R, Kakaei F, Abedi R, Kabir-Mamdooh B. Conjugated linoleic acid improves glycemic response, lipid profile, and oxidative stress in obese patients with non-alcoholic fatty liver disease: a randomized controlled clinical trial. Whereas its manufacturer created it for a sole purpose of helping people shed pounds easier – the supplement’s main ingredient has an area of action far wider and much more complex than that. Lipids Health Dis. Conjugated linoleic acid comes with uncomfortable side effects on fatty foods, the actual main reason for cardiovascular disease and cancers illnesses. Other side effects while taking CLA are extremely rare as well since is a naturally occurring fatty acid. Very severe CLA side effects may include the following: Such side effects may require medical attention and immediate discontinuation of the supplement. View abstract. Acute oral safety study of dairy fat rich in trans-10 C18:1 versus vaccenic plus conjugated linoleic acid in rats. View abstract. Venkatramanan, S., Joseph, S. V., Chouinard, P. Y., Jacques, H., Farnworth, E. R., and Jones, P. J. Consuming CLA in its natural form in food is considered safe. Brands generally prefer Safflower Oil to make CLA due to the high yield and efficiency in the manufacturing process (i.e., getting the most CLA … View abstract. Islam, M. A., Kim, Y. S., Jang, W. J., Lee, S. M., Kim, H. G., Kim, S. Y., Kim, J. O., and Ha, Y. L. A mixture of trans, trans conjugated linoleic acid induces apoptosis in MCF-7 human breast cancer cells with reciprocal expression of Bax and Bcl-2. Biosci.Biotechnol.Biochem. Prog Lipid Res 2001;40(4):283-298. View abstract. J Nutr Biochem. The subject reported experiencing rapid heart beat, nausea, increased hunger and trouble falling asleep, according to the NIH presentation. View abstract. Anticancer Res 1997;17(1A):197-203. View abstract. View abstract. McClelland, S., Cox, C., O'Connor, R., de Gaetano, M., McCarthy, C., Cryan, L., Fitzgerald, D., and Belton, O. Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cell. Effect of conjugated linoleic acid associated with aerobic exercise on body fat and lipid profile in obese women: a randomized, double-blinded, and placebo-controlled trial. Many men taking finasteride experience a slowing of hair loss, and some may show new hair growth. View abstract. Brownbill, R. A., Petrosian, M., and Ilich, J. Schoeller, D. A., Watras, A. C., and Whigham, L. D. A meta-analysis of the effects of conjugated linoleic acid on fat-free mass in humans. Exp Gerontol 2016;85:1-11. Choi, J. S., Koh, I. U., Jung, M. H., and Song, J. A. Kimoto, N., Hirose, M., Futakuchi, M., Iwata, T., Kasai, M., and Shirai, T. Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats. Identification of conjugated linoleic acids in hydrogenated soybean oil by silver ion-impregnated HPLC and gas chromatography-ion impacted mass spectrometry of their 4,4-dimethyloxazoline derivatives. Hyperglycemia (high blood sugar) has been reported in some people because CLA may cause insulin resistance. Belury MA, Mahon A, Banni S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. Murru E, Carta G, Cordeddu L, et al. Effects of conjugated linoleic acid on insulin sensitivity and diabetes markers in type 2 diabetic patients. View abstract. Rossary, A., Arab, K., and Steghens, J. P. Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts. However, it doesn't seem to reduce the need to use inhalers or improve the volume of air the lungs can hold. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. Brown, J. M., Boysen, M. S., Chung, S., Fabiyi, O., Morrison, R. F., Mandrup, S., and McIntosh, M. K. Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. Moloney, F., Yeow, T. P., Mullen, A., Nolan, J. J., and Roche, H. M. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Hunt, W. T., Kamboj, A., Anderson, H. D., and Anderson, C. M. Protection of cortical neurons from excitotoxicity by conjugated linoleic acid. While these weight loss effects may be statistically significant, they are small — and there is potential for side effects. In Vitro Cell Dev Biol Anim 2003;39(8-9):375-382. J Biol.Chem. Nutrition 2009;25(7-8):800-811. Johnson, LW. Petridou, A., Mougios, V., and Sagredos, A. Supplementation with CLA: isomer incorporation into serum lipids and effect on body fat of women. Diabetes Res Clin.Pract. View abstract. View abstract. Atherosclerosis 2010;211(1):96-102. 2007;18(7):467-474. View abstract. Valeille, K., Gripois, D., Blouquit, M. F., Souidi, M., Riottot, M., Bouthegourd, J. C., Serougne, C., and Martin, J. C. Lipid atherogenic risk markers can be more favourably influenced by the cis-9,trans-11-octadecadienoate isomer than a conjugated linoleic acid mixture or fish oil in hamsters. Halade, G. V., Rahman, M. M., Williams, P. J., and Fernandes, G. Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice. The same is true for Tonalin, a dietary supplement meant to reduce body fat. View abstract. J Nutr Biochem. Turpeinen, A. M., Ylonen, N., von Willebrand, E., Basu, S., and Aro, A. Immunological and metabolic effects of cis-9, trans-11-conjugated linoleic acid in subjects with birch pollen allergy. Although CLA (conjugated linoleic acid) is a popular supplement for slimming, there is some evidence it could have negative effects on the liver. 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